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Fabrice Gritti | Chemistry | Excellence in Innovation

Research Scientist at Waters Corp, United States.

Dr. Fabrice Gilles Ernest Gritti is a highly accomplished consulting research scientist at Waters Corporation, where he leads pioneering research in separation sciences and liquid chromatography. With over 20 years of experience, Dr. Gritti has significantly contributed to the development of innovative chromatographic technologies for pharmaceutical and life sciences industries. His work focuses on improving the efficiency and resolution of chromatographic columns and instruments, leading to faster and more accurate bioanalytical methods. He has authored more than 305 peer-reviewed articles, earned over 10,000 citations, and holds 16 patents, underscoring his impact on both academia and industry. He collaborates extensively with leading institutions like Princeton University and Marburg University, ensuring his research remains at the cutting edge. With a deep commitment to innovation, Dr. Gritti continues to push the boundaries of chromatography and its applications in life sciences.

📚 Profile

ORCID

🎓 Education

Dr. Gritti’s educational foundation is rooted in physical chemistry and condensed matter physics. He earned a Bachelor’s degree in Physical Chemistry in 1995, followed by an Engineer’s degree from the School of Physics and Chemistry of Bordeaux in 1997. His academic pursuit culminated with a Ph.D. in Physics and Chemistry of Condensed Matter from University of Bordeaux I in 2001. His doctoral research laid the groundwork for his future specialization in chromatographic sciences. His strong foundation in chemistry and physics enables him to approach chromatography with a unique blend of theoretical insight and practical application. Postdoctoral work in chromatographic sciences from 2002 to 2014 further sharpened his expertise, allowing him to make groundbreaking contributions in both fundamental science and industrial applications.

💼 Experience

Dr. Gritti began his career with a strong focus on the fundamentals of chromatographic sciences, engaging in post-doctoral research from 2002 to 2014. During this period, he gained a deep understanding of liquid chromatography (LC) and its applications in separation sciences. In 2015, he joined Waters Corporation, where he has since worked on the development of next-generation chromatographic columns and instrumentation for the pharmaceutical industry. His current responsibilities include managing both internal and external research collaborations with prestigious institutions such as Princeton University and Marburg University. His role involves overseeing advanced research programs aimed at delivering innovative solutions for life sciences, such as fast, high-resolution bio-analyzers. His experience spans a balance of theoretical research, practical industrial applications, and cross-institutional collaborations, all contributing to his exceptional expertise.

🔬 Research Interests

Dr. Gritti’s research interests lie at the intersection of separation sciences and chromatography, with a focus on enhancing the performance and understanding of liquid chromatography. His work delves into the thermodynamics of liquid/solid adsorption, band broadening in chromatographic columns, and mass transfer in heterogeneous media. He is particularly interested in the development of new chromatographic methods that enable faster, more specific, and higher-resolution separations in bioanalytical applications. His ongoing research explores innovative techniques like slalom chromatography in cell and gene therapy, as well as advancements in mRNA characterization and dsRNA detection. By continuously refining chromatographic techniques, Dr. Gritti contributes to faster and more precise separation methods that are critical in pharmaceutical research and other life sciences fields.

🏆 Awards and Honors

Dr. Gritti has received numerous accolades throughout his career in recognition of his outstanding contributions to separation sciences and chromatography. His innovations in chromatographic column design and bioanalytical instrumentation have earned him multiple awards from industry and academic organizations. He holds 16 patents, which highlight his focus on practical innovations that have direct applications in pharmaceutical and life sciences research. In addition to his patents, Dr. Gritti has received over 10,000 citations and boasts an H-index of 56, underscoring the global impact of his work. His editorial appointment with the Journal of Chromatography A further demonstrates his influence in shaping the future direction of chromatographic research.

🔚 Conclusion

Dr. Fabrice Gritti’s substantial contributions to innovative chromatographic technologies and his leadership in industry-driven research make him an excellent candidate for the Research for Excellence in Innovation award. His work not only advances the field of separation sciences but also has real-world applications in life sciences and pharmaceuticals. With a few minor improvements, such as broader interdisciplinary focus and educational outreach, he could further solidify his standing in the global research community. Overall, he demonstrates the qualities that align well with the award’s focus on innovation and research excellence.

Publications Top Notes 📚

Title: “Theoretical predictions to facilitate the method development in slalom chromatography for the separation of large DNA molecules”
Author: Fabrice Gritti
Year: 2024
Citation: Gritti, F. (2024). Theoretical predictions to facilitate the method development in slalom chromatography for the separation of large DNA molecules. Journal of Chromatography A, 465379. https://doi.org/10.1016/j.chroma.2024.465379

 

Title: “Harnessing an elastic flow instability to improve the kinetic performance of chromatographic columns”
Author: Fabrice Gritti
Year: 2024
Citation: Gritti, F. (2024). Harnessing an elastic flow instability to improve the kinetic performance of chromatographic columns. Journal of Chromatography A, 465326. https://doi.org/10.1016/j.chroma.2024.465326

 

Title: “Understanding retention and intra-particle diffusivity of alkylsulfobetaine-bonded Ethylene Bridged Particles with different mesopore sizes for hydrophilic interaction liquid chromatography applications”
Author: Fabrice Gritti
Year: 2024
Citation: Gritti, F. (2024). Understanding retention and intra-particle diffusivity of alkylsulfobetaine-bonded Ethylene Bridged Particles with different mesopore sizes for hydrophilic interaction liquid chromatography applications. Journal of Chromatography A, 465232. https://doi.org/10.1016/j.chroma.2024.465232

 

Title: “Retention mechanism in combined hydrodynamic and slalom chromatography for analyzing large nucleic acid biopolymers relevant to cell and gene therapies”
Author: Fabrice Gritti
Year: 2024
Citation: Gritti, F. (2024). Retention mechanism in combined hydrodynamic and slalom chromatography for analyzing large nucleic acid biopolymers relevant to cell and gene therapies. Journal of Chromatography A, 465075. https://doi.org/10.1016/j.chroma.2024.465075

 

Title: “Preparation and investigation of two-component silica-modified hydrophobic layer for minimizing retention loss of reversed-phase chromatographic columns using fully aqueous mobile phases”
Author: Fabrice Gritti
Year: 2024
Citation: Gritti, F. (2024). Preparation and investigation of two-component silica-modified hydrophobic layer for minimizing retention loss of reversed-phase chromatographic columns using fully aqueous mobile phases. Journal of Chromatography A, 464766. https://doi.org/10.1016/j.chroma.2024.464766

Fabrice Gritti | Chemistry | Excellence in Innovation

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