Research Scientist-I at Versiti Blood Research Institute, United States.
Dr. Ramoji Kosuru is an accomplished cell and vascular biologist 👨🔬 currently serving as a Postdoctoral Fellow and Research Scientist-I at the Versiti Blood Research Institute in Milwaukee, USA 🧬🇺🇸. With a deep focus on cardiovascular and metabolic disorders, Dr. Kosuru has made pioneering contributions in endothelial Rap1 signaling, nitric oxide regulation, and diabetic cardiomyopathy 💓. His research has been featured in high-impact journals like ATVB, IJMS, Angiogenesis, and Frontiers in Pharmacology 📚. Beyond bench science, he also serves as an academic editor for prestigious journals, reflecting his leadership in the field 🖋️. Known for his innovation, precision, and collaboration, Dr. Kosuru blends pharmacological insight with molecular biology expertise to address complex cardiovascular challenges 🔍❤️. His global collaborations and fellowships signify a rising scientific star with strong translational potential 🌍✨.
Professional Profile:
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Suitability For Best Researcher Award – Mr. Ramoji Kosuru
Dr. Ramoji Kosuru is exceptionally suitable for the Best Researcher Award due to his sustained and innovative contributions in cardiovascular biology, particularly in the molecular mechanisms governing endothelial function, nitric oxide regulation, and diabetic cardiomyopathy. His work spans the intersection of pharmacology and cell signaling, blending foundational science with translational potential. Currently positioned as a Postdoctoral Fellow and Research Scientist-I at the Versiti Blood Research Institute (USA), Dr. Kosuru has built an internationally recognized profile supported by over 35 peer-reviewed publications, editorial responsibilities, and advanced technical skills.
🎓 Education
Dr. Ramoji Kosuru began his academic journey with a Bachelor’s in Pharmacy (B.Pharm.) from Acharya Nagarjuna University, India 🇮🇳. He advanced to earn a Master’s in Pharmacology (M.Pharm.) from Andhra University 📘. His thirst for scientific discovery led him to the prestigious Indian Institute of Technology (BHU), Varanasi, where he completed his Ph.D. in 2018, focusing on Diabetic Cardiomyopathy 🔬💉. To pursue advanced research, he moved to the United States, where he undertook Postdoctoral training in Vascular Signaling at Versiti Blood Research Institute, Wisconsin, and currently holds a Research Scientist-I position 🎓🧠. His academic path highlights an exceptional blend of pharmacy, pharmacology, and cutting-edge cardiovascular research 🧪💖.
💼 Experience
Dr. Kosuru’s professional journey began as a Graduate Student at IIT-BHU (2012–2018) where he developed natural product therapies for diabetic heart disease 🌿❤️. Post-Ph.D., he joined Versiti Blood Research Institute in Wisconsin as a Postdoctoral Fellow (2018–Present), later progressing to Research Scientist-I 👨🔬. His ongoing research explores the role of Rap1 GTPases in endothelial function and nitric oxide signaling 🧬🩸. He’s contributed to over 35 publications, several as a lead author, and is well-versed in in vitro, in vivo, and molecular techniques 🧫🧪. His active participation in interdisciplinary collaborations and mentoring roles demonstrates a growing leadership trajectory in biomedical sciences 🧠💼.
📈 Professional Development
Dr. Kosuru has continually enhanced his professional capabilities through cutting-edge research, mentorship, and editorial duties 📚💡. He has mastered advanced techniques like endothelial calcium imaging, NO assays, and gene silencing, contributing novel insights into cardiovascular pathophysiology 🔬❤️. His postdoctoral training under Dr. Chrzanowska has equipped him with grant writing, international conference presentations, and collaboration-building skills 🌐📊. He also serves as an Academic Editor for Oxidative Medicine and Cellular Longevity and BioMed Research International, demonstrating his growing authority in the field ✍️🧠. As a member of ASCB and NAVBO, Dr. Kosuru remains connected to leading scientific networks. With a proven record of publishing, reviewing, and mentoring, he exemplifies a well-rounded, impactful researcher dedicated to continuous growth and contribution 🔄🌟.
🧪 Research Focus
Dr. Kosuru’s research primarily focuses on Cardiovascular Biology, with particular emphasis on endothelial signaling, vascular homeostasis, diabetic cardiomyopathy, and vascular immunosuppression 🫀🧬. His work on Rap1 isoforms (Rap1A & Rap1B) has revealed novel regulatory pathways involving calcium signaling and nitric oxide synthesis, shedding light on mechanisms underlying heart failure, inflammation, and vascular dysfunction 🔍⚠️. Additionally, his research bridges into metabolic diseases such as diabetes, using natural products to modulate oxidative stress and apoptosis 🌿⚡. Recently, he’s contributed to uncovering vascular immune evasion mechanisms in cancer, offering potential therapeutic targets in immuno-oncology 💉🎯. Dr. Kosuru’s approach integrates cell biology, pharmacology, and translational medicine, making his work relevant for cardiovascular therapy, metabolic health, and immune modulation in vascular biology 🚑🧠.
🧠 Research Skills
Dr. Kosuru possesses a rich repertoire of technical skills across molecular pharmacology, vascular biology, and cell signaling 🧬🔬. He specializes in endothelial function assays, including calcium imaging, NO measurement, and store-operated calcium entry (SOCE) modulation 🔍🧪. His expertise extends to Western blotting, ELISA, qPCR, animal models of diabetes and ischemia-reperfusion injury, and natural compound-based drug discovery 🌿💊. Dr. Kosuru also brings solid experience in nanocarrier formulation, pharmacokinetics, and translational preclinical models, making him adept at bridging basic research and therapeutic application 🚀⚗️. He’s proficient in scientific communication, grant writing, manuscript preparation, and collaborative research leadership 🧠✍️. His integrative and multidisciplinary skill set is tailored for innovation in cardiovascular, metabolic, and inflammatory disease research 🔧💖.
🏆 Awards & Honors
Dr. Ramoji Kosuru has earned notable accolades throughout his academic and research journey 🏅🎓. He received the Richard S. Gallagher Fellowship from Versiti Blood Research Institute in 2021 🌟, recognizing his excellence in cardiovascular research. Earlier, he was honored with the Prof. Govind Achari Award by the Indian Pharmacological Society in 2017 for the best oral presentation 🗣️🏆. He has also held prestigious scholarships like the UGC Fellowship (2006–2008) and the Institute Teaching Assistantship from MHRD during his Ph.D. years 📘🎖️. These honors underline his academic rigor, innovation, and growing reputation as a leader in biomedical sciences 📚💼.
Publication Top Notes
1. Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression
Authors: GP Sharma, R Kosuru, S Lakshmikanthan, et al.
Journal: Angiogenesis, 2023, 26(2): 265–278
Citations: 7
Summary:
This study identifies a new role for endothelial Rap1B in suppressing immune cell infiltration into tumors, thereby facilitating tumor growth. It uncovers a novel mechanism of vascular immunosuppression.
2. Natural products targeting oxidative stress and cell death: Treatment potential in metabolic and cardiovascular diseases
Authors: R Kosuru, Y Cai, V Tiwari
Journal: Frontiers in Pharmacology, 2023, 14: 1141878
Citations: 5
Summary:
This review explores various natural compounds that influence oxidative stress and cell death, evaluating their therapeutic prospects for treating metabolic and cardiovascular diseases.
3. Role of AMPK in Myocardial Ischemia‐Reperfusion Injury‐Induced Cell Death in the Presence and Absence of Diabetes
Authors: N Kandula, S Kumar, VKK Mandlem, et al.
Journal: Oxidative Medicine and Cellular Longevity, 2022, Article ID: 7346699
Citations: 13
Summary:
The paper investigates how AMPK functions during myocardial injury due to ischemia-reperfusion, comparing effects in diabetic and non-diabetic conditions to understand its role in cardiac cell survival.
4. Formulation, Optimization, and In Vitro Characterization of Dasatinib Loaded Polymeric Nanocarriers to Extend the Release of the Model Drug
Authors: RK Sandeep Kumar Reddy Adena, Kasi Viswanadh Matte
Journal: International Journal of Applied Pharmaceutics, 2021, 13(5): 318–330
Citations: 4
Summary:
This research focuses on designing and optimizing polymeric nanoparticles for controlled release of Dasatinib, aiming to enhance its therapeutic profile.
5. Distinct signaling functions of Rap1 isoforms in NO release from endothelium
Authors: R Kosuru, B Singh, S Lakshmikanthan, et al.
Journal: Frontiers in Cell and Developmental Biology, 2021, 9: 687598
Citations: 9
Summary:
The study examines the individual roles of Rap1A and Rap1B proteins in regulating nitric oxide production from endothelial cells, revealing distinct signaling pathways.
6. Endothelial Rap1 restricts inflammatory signaling to protect from the progression of atherosclerosis
Authors: B Singh, R Kosuru, S Lakshmikanthan, et al.
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(2): 638–650
Citations: 49
Summary:
This article highlights the protective function of endothelial Rap1 in vascular inflammation and atherosclerosis, demonstrating its potential as a therapeutic target.
7. Preclinical evidence of the therapeutic role of Pterostilbene: focus on the mitochondria
Authors: R Kosuru, MR Vijayakumar, S Singh
Book Chapter: Mitochondrial Physiology and Vegetal Molecules, 2021, Pages 301–315
Citations: 2
Summary:
This chapter reviews the mitochondrial benefits of pterostilbene based on preclinical evidence, discussing its potential utility in disease prevention and health promotion.
8. Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation
Authors: ZX Qiqi Zhu, Haobo Li, Xiang Xie, Xiaozhen Chen, Ramoji Kosuru, et al.
Journal: Oxidative Medicine and Cellular Longevity, 2020
Citations: 20
Summary:
The paper studies adiponectin’s cardioprotective effects post-ischemia by activating both AMPK-dependent and independent signaling, emphasizing its dual mechanism of action.
🏁 Conclusion
Dr. Ramoji Kosuru stands out as a transformative figure in biomedical research, particularly in vascular biology and metabolic disease. His trajectory from India to a leading U.S. research institute, combined with novel mechanistic discoveries, strong publication record, editorial leadership, and technical versatility, exemplifies excellence, innovation, and global relevance. He not only meets but exceeds the standards typically expected for the Best Researcher Award—making him a compelling and well-qualified nominee.